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Correspondence to Author: Abdulmabod Omar^1,2, Mohamed Gamil Mehanna³, Ashraf Hawsawi ⁴, Somaya Fouad Koshak⁵, Aisha Ibrahim Aljefri⁶, Maimonah Fuad Koshak⁷, Marwah Abdulhamid Hadidi⁸, Yasir Osamah Abushuaylan⁹, Awad Abdelmonim ¹⁰, Sulafah Mohammed Abdu Yammani⁵, Maram Abduallah Algarni¹¹, Ahad Ahmed Alhusaini¹², Wijdan Yahya Abualkheir¹³, Namarig Kamaleldin Babiker Abashar¹⁴, Taif Abdullah Alharbi⁷, Hind Abdulrazaq Alanazi⁷Abdalluh Jaber Alsharari ⁷, Mohammed Samir Bohkari⁶, Sami Lafi Alsharari ⁷, Mohammed Ali Alamri ⁷. 

1. Laboratory Department , Hassan Ghazzawi Hospital, Abeer Medical Group, Jeddah , KSA
2. Department of clinical pathology, Faculty of medicine, Al Azhar university, Cairo , Egypt
3. Biochemistry department, king Abdulaziz University, Jeddah, Saudi Arabia
4. Laboratory Department, Security Forces Hospital-Makkah, KSA.
5. ER Department, King Fahd Armed Forces Hospital: Jeddah, Mecca Region, and KSA.
6. Laboratory Department, Dr. Erfan and Bagdo general hospital, Jeddah, KSA.
7. Medical Laboratory Department, King Salman Armed Forces Hospital. Tabuk, KSA.
8. Laboratory Department, Dr.Sulaiman Al Habib hospital, Jeddah, KSA.
9. Laboratory Department,Ministry of National Guard - Health Affairs, Jeddah, KSA.
10. Faculty of medicine, University of Khartoum. Khartoum Sudan.
11. Laboratory Department, Dr. Samir Abbas Hospital, Jeddah, KSA.
12. Wahat Al Shifa Medical Complex - 3, Jeddah, KSA.
13. Medical nutrition and laboratory, University College London, United Kingdom.
14. Medical Laboratory Department, Dr. Soliman Fakeeh Hospital, Jeddah, KSA.

DOI: 10.52338/jocem.2025.4777

Abstract:

Background:Chronic depression is characterized by the dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and has several effects on cortisol and DHEAS production. These hormonal changes have been seen in depressive disorders, but their diagnostic value is still a matter of question.

objective:This study evaluates the correlation between cortisol and DHEA-S levels in individuals with chronic illness and their potential as biomarkers for disease severity.
Methodology: A quantitative case-control study was done on 40 patients with chronic stress-related endocrine dysfunction and in 20 healthy controls. Electrochemiluminescence immunoassay (ECLIA) was applied for hormonal assays of cortisol and dehydroepiandrosterone sulfate (DHEA-S). A statistical analysis was performed to compare the groups.
Results: The results of the study showed that patients had reduced cortisol and DHEA-S levels. Therefore, these findings indicated the existence of a strong, significant relationship between chronic stress and endocrine disturbances.
Conclusion: These findings provide evidence for the hypothesis that HPA-DX, reduced cortisol and DHEA-S levels, is the phenotypic endophenotype of chronic depression. These changes may have effects on the diagnosis of the severity of the condition or the effectiveness of the treatment for depression. Future studies should, therefore, consider establishing their effectiveness in estimating the effectiveness of antidepressants as far as the prospect of mental health status is concerned.

Keywords:Hormonal Dysregulation, DHEA-S, Stress-Related Endocrinopathy, ECLIA, HPA Axis, Fatigue Syndrome.

Citation:

Dr.Abdulmabod Omar, Exploring The Diagnostic Association Between Cortisol And DHEA-S Concentrations In Patients Experiencing Chronic Depressive Disorders. Journal of Clinical Endocrinology and Metabolism 2025.