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Correspondence to Author: Rita AnEtonelli, Oslei Paes de ARlmeida, Ronell Bologna-Molina and MarRco Meleti. 

Department of Chronic Surgery, Al-Azhar University, Cairo, Egypt

Abstract:

Context. Diagnosing Sialadenoma papilliferum (SP), a rare benign epithelial tumor of salivary gland origin, can be difficult. It was initially identified as an analog of the cutaneous syringocystadenoma papilliferum by Abrams and Finck in 1969. Through the analysis of previously published cases and the reporting of new cases, this thorough review seeks to highlight the clinical and histological diagnostic characteristics of intraoral SP. Techniques. Up until February 2022, Medline, Scopus, and Web of Science were searched using the entry word “sialadenoma papilliferum.” Only English-language studies were considered, and there were no time restrictions. Only mouth-related cases were covered. Letters to the editor, personal correspondence, and conference proceedings were not included. outcomes. Overall, The palate, especially the hard palate, was the area most impacted. There have been reports of four cases with unclear malignant characteristics. The preferred treatment for SP is conservative excision because of its low growth potential, unusual histological and immunohistochemical characteristics, and somewhat nonspecific clinical symptoms (such as submucosal edema with ulceration). Conclusions.Even though SP is uncommon, it should be considered when making a differential diagnosis for intraoral swellings, especially those that are on the palate. Typically, there is an erythematous patch inside a mucosa that is otherwise normal (Figure 1A). Based on the keratotic appearance of the papillary surface, papilloma is the most common differential diagnosis. Soft tissues neoplasms, pyogenic granulomas, palatal fistulas, and other benign and malignant small salivary gland tumors are additional clinical diagnostic theories.

Keywords:sialadenoma papilliferum; salivary gland tumors; oral pathology; oral medicine; oral surgery.

Citation:

Dr.Rita AnEtonelli, Intraoral Sialadenoma Papilliferum: A Comprehensive Review Of The Literature With Emphasis On Clinical And Histopathological Diagnostic Features. Journal of Nature Conservation Science 2025.