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Correspondence to Author: Délio Tiago Martins Malaquias^1-2, Ana Luiza Zampar Quintana Gomes¹⁰,MBiatriz Cavalcante Silva^1-6,Daniel Rubens Freitas Facundo^1-6, Lígia dos Santos Marteline^1-6, Nicole Silva dos Santos^1-6, Letícia Borghetti Calil^1-6, Christian Emmanuel da Silva Pelaes^1-6, Pietra Kananovicz Fernandes^1-6, Ana Laura Diniz Campozana¹, Giovana Casarini Yamashiro³, Beatriz Randone Pereira³, Guilherme Pio Vilela³, Jaqueline de Carvalho Ferreira³, Keldna Karine da Silva Paiva¹, Samantha Regina Galo Sanches¹, Bárbara Leitão⁶, Aghata Cruz Abreu ¹, Rafael Pinheiro do Nascimento⁴, Raquel Perez Carvalho^1-6, Giovana Barreto Lima de Oliveira⁷, Adriana F. Viana¹, Victoria Cristina Galbes Moretti⁷,Rubens Rodrigues Tudela⁸, Juliana Fontes Beltran Paschoal^1-5, Thalita Pinheiro Morel Alineri¹¹,Liliana Martins Occulate¹², Joel Eloi Belo Junior¹³, Thiago Augusto Rochetti Bezerra^1-6-9. 

1. Medical student. University of Ribeirão Preto (UNAERP). Guarujá Campus, São Paulo, Brazil.
2. Graduated in Physiotherapy from the University of Mogi das Cruzes; Postgraduate in Respiratory Physiotherapy and Pediatric Intensive Care and Neonatology from the University of São Paulo, São Paulo/SP, Hospital Physiotherapy, Bahiana School of Medicine and Public Health. Salvador/BA, Brazil.
3. Medical student. Nove de Julho University, São Bernardo do Campo, São Paulo, Brazil.
4. Medical student. Nove de Julho University, Vergueiro. São Paulo, Brazil.
5. PhD Biotechnology University of São Paulo (USP). São Paulo, Brazil.
6. Member of the Pneumology Academic Program (UNAERP). Guarujá Campus, São Paulo, Brazil.
7. Medical student. Professor Franco Montoro Municipal College. Mogi Guaçu. São Paulo, Brazil.
8. Medical student. São Judas Tadeu. Cubatão, São Paulo, Brazil.
9. PhD in Medical Sciences. University of São Paulo (USP). Ribeirão Preto Medical School. São Paulo, Brazil.
10. Medical student. University Prof. Edson Antônio Velano. Unifenas, Alfenas, Minas Gerais, Brazil.
11. Medical student. Universidade do Oeste Paulista (UNOESTE). Guarujá, São Paulo, Brazil.
12. Medical student. Universidad Central del Paraguay. Ciudad del Este, Paraguay.
13. Master’s degree in Operational Human Performance. Master’s student in Intellectual Property and Technology Transfer for Innovation.

DOI: 10.52338/jrmr.2025.4713

Abstract:

Chronic Obstructive Pulmonary Disease (COPD) is a progressive respiratory disease associated with high morbidity and mortality, especially in acute exacerbations that require admission to the Intensive Care Unit (ICU) and invasive ventilatory support. Considering the pathophysiological complexity of COPD, standardized therapies are not always effective and individualized management is necessary. This study aimed to critically analyze the available evidence on personalized therapies in COPD patients under mechanical ventilation. Specifically, it sought to identify ventilatory adjustments and individualized pharmacological interventions, as well as to assess their impact on clinical outcomes.This is a systematic review of the literature carried out in five databases, including studies published between 2013 and 2024 that addressed personalized therapies in COPD under invasive mechanical ventilation. Studies focusing exclusively on non-invasive ventilation or case reports were excluded. The results show that detailed physiological assessment, using tools such as electrical impedance tomography and esophageal catheter, allows for personalized titration of parameters such as PEEP and ΔP. In addition, pharmacotherapy adjusted to inflammatory phenotypes and clinical condition showed a reduction in ventilation time, a higher rate of successful weaning and lower hospital mortality. It is concluded that personalization of ventilatory and pharmacological therapy in COPD patients in the ICU contributes to more favourable outcomes, reinforcing the need to incorporate strategies based on physiology and individual variability into intensive care practice.

Keywords:Chronic Obstructive Pulmonary Disease; Mechanical Ventilation; Intensive Care Unit; Ventilatory Weaning

Citation:

Dr.Thiago Augusto, Personalized Therapies For Chronic Obstructive Pulmonary Disease (Copd) And Acute Respiratory Failure In Mechanically Ventilated Patients.. Journal of Respiratory Medicine and Research 2025.