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Correspondence to Author: Filiwppo Antonacci, Mateteo Petroncini, Eleqna Salvaterra, Pieftro Bertoglio, Nicecfdolò Daddi, Gixsuleia Lai,Juvry Branddolini, Piergiorgdio Solli and Gidampiero Dolci. . 

BIOARABA Health Research Institute. OSI Araba. University Hospital. UPV/EHU, Vitoria, Spain.

Abstract:

Despite the WHO’s declaration that the pandemic emergency is over, patients with impaired immune systems are still at risk from COVID-19. Over the past two years, the COVID-19 pandemic has spread over the world and claimed a considerable number of lives. Although the initial lethality of SARS-CoV-2 has diminished after three years, immunocompromised patients have a much worse prognosis despite an initially positive clinical course following COVID-19. The patient’s condition rapidly worsened and they passed away within a few days as a result of substantial lung involvement.This instance demonstrates how unpredictable COVID-19 patients are in comparison to the general population, particularly those who have had lung transplants. Two interesting case reports that illustrate the intricate difficulties associated with COVID-19 infection in lung transplant recipients are presented in this publication. The initial instance focuses on a patient who underwent a kidney transplant in 2022 after receiving a bilateral lung transplant in 2009 for pulmonary artery hypertension. Despite a promising clinical outcome at first after catching COVID-19, the patient’s condition quickly worsened and, as a result of widespread lung involvement, they passed away within a few days. This example demonstrates the unpredictability of COVID-19 and its potentially fatal effects on recipients of lung transplants. The second instance is a patient who suffered from chronic obstructive pulmonary disease (COPD) and had bilateral lung transplantation five years prior. In addition to having pre-existing conditions such as diffuse bronchial stenosis and chronic lung allograft rejection (CLAD), this person also got COVID-19. The patient’s clinical state rapidly worsened after the viral infection, with bronchial stenosis getting worse.This instance demonstrates how COVID-19 can make pre-existing lung issues worse in transplant recipients. These incidents demonstrate the critical necessity for heightened awareness and specialized treatment approaches when it comes to COVID-19 in lung transplant recipients. The disease’s unpredictable and harmful progression in these individuals emphasizes how crucial it is to put tight preventative measures in place for this susceptible group, including immunization and rigorous adherence to infection control procedures.To fully comprehend the distinct dynamics of COVID-19 in lung transplant recipients and to create focused therapies to enhance their results, more research is necessary.

Keywords: lung transplant; COVID-19; chronic lung allograft rejection.

Citation:

Dr.Filiwppo Antonacci, Reports Of Two Cases Concerning Lung Transplant Recipients And Covid-19. World Journal Of Chronic Diseases 2025.