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Correspondence to Author: Reham Z. Hamza 

Reham Z. Hamza, Department of Zoology, Faculty of Science, Zagazig University, Zagazig, Egypt.

Abstract: There is ongoing debate on the possible advantages of zinc oxide nanoparticles (ZnO NPs) made by green synthesis. The current study set out to clarify how green tea leaf extract (GTE)/ZnO NPs complexes counter monosodium glutamate (MSG)-induced hyperlipidemia. Supplies and Procedures: There were eight distinct groups of male rats used: Group I served as the reference point. Groups IV and V received MSG in two different doses (6.0 and 17.5 mg kgG1), Group VI received ZnO NPs/GTE complex, Group VII and VIII received ZnO NPs/GTE complex with MSG in different doses, while Group II received GTE (1 mg mLG1). Group III received ZnO NPs (10 mg kgG1). ZnO NPs/GTE complex’s protective efficacy against MSG toxicity through research ZnO NPs/GTE complex’s protective effect against MSG toxicity has been reported, based on an analysis of changes in lipid profiles and liver function enzyme activity (alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), alkaline phosphatase (ALK), and γ-glutamyl transferase (γ-GT). The rats that received MSG only experienced substantial alterations in lipid metabolism and a highly significant rise in liver enzymes. Results: By enhancing both the lipid profile and liver enzyme activity, the group VII and VIII results provide insight into the effectiveness of ZnO NPs/GTE complex as a hepato-protectant when taken alone with MSG.Serum γ-GT, ALP, LDH, ALT, and AST activity were all markedly decreased. In summary, ZnO NPs/GTE complex has demonstrated potential hepatoprotective properties by drastically reducing the MSG-induced hepatotoxicity via the reduction of hyperlipidemia.

Keywords: ZnO NPs/Green tea complex, lipid profile, liver biomarker enzymes

Citation:

Reham Z. Hamza. Effects of Nanoparticles on Zinc Oxide/Green Tea Complex on Rats’ Lipid Profile and Liver Functions Following Treatment with Monosodium Glutamate. Jounal of Applied Sciences 2024.